TMG

betaine anhydrous

A methyl donor often stacked with NAD+ precursors "to support methylation." What it demonstrably does is lower homocysteine; the rest is extrapolation.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

homocysteine lowering — grade B, moderate effect (human-rct)

Olthof et al. (2003)

species humandesign RCT, double-blindn 76duration 6 weeksdose 1.5–6 g/dayfunding publicoutcome plasma homocysteine

Dose-dependent ~10–20% reduction, well replicated. Whether lowering homocysteine this way prevents anything is a different, unproven claim.

strength & power performance — grade C, unclear effect (human-rct)

Grade timeline

No grade movement since first review.

Dosing & safety

TYPICAL SUPPLEMENT DOSE500–2000 mg/day

DOSES USED IN STUDIES2–6 g/day (homocysteine trials)

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

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