Quercetin

dihydrate · phytosome

A plant flavonoid promoted as a senolytic, almost always on the strength of combination studies with the chemotherapy drug dasatinib. Alone, in humans, there is very little.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

clearing senescent cells (senolytic effect) — grade D, unclear effect (in-vitro)

Hickson et al. (2019)

species humandesign open-label pilot (D+Q combination)n 9duration 11 daysdose dasatinib 100 mg + quercetin 1000 mg, 3 daysfunding publicregistry NCT02848131outcome senescence markers in adipose tissue

Senescence markers fell — in nine people, unblinded, and with dasatinib in the mix. Quercetin's own contribution is unknown; alone it fails as a senolytic in most cell lines.

upper respiratory infection prevention — grade C, small effect (human-rct)

Grade timeline

No grade movement since first review.

Dosing & safety

TYPICAL SUPPLEMENT DOSE500–1000 mg/day

DOSES USED IN STUDIES500–1000 mg/day; senolytic protocols use intermittent D+Q dosing

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

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