NR / NMN

NR chloride · NMN

NAD+ precursors and the flagship compounds of the longevity boom. They reliably raise blood NAD+ — and so far that is nearly the whole human story.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

raising blood NAD+ levels — grade B, large effect (human-rct)

Martens et al. (2018)

species humandesign RCT, double-blind crossovern 24duration 6 weeksdose 1000 mg NR/dayfunding mixedregistry NCT02921659outcome blood NAD+ metabolome, vascular measures

NAD+ up ~60%, replicated across trials. Raising the biomarker is settled; whether raising it does anything for aging humans is not.

healthspan & lifespan extension — grade D, moderate effect (rodent)

Mills et al. (2016)

species rodentdesign controlled long-term studyn 80duration 12 monthsdose 100–300 mg/kg/day NMNfunding mixedoutcome metabolic decline, physical function in aging mice

Broad improvements in aging mice. Nobody has tested this endpoint in humans, and at these doses nobody soon will.

insulin sensitivity in prediabetic women — grade C, small effect (human-rct)

Yoshino et al. (2021)

species humandesign RCT, double-blindn 25duration 10 weeksdose 250 mg NMN/dayfunding publicregistry NCT03151239outcome muscle insulin sensitivity (clamp)

A real but isolated metabolic signal in one small, specific population.

Grade timeline

No grade movement since first review.

Dosing & safety

TYPICAL SUPPLEMENT DOSE250–1000 mg/day

DOSES USED IN STUDIES250–2000 mg/day

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

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