Lion's mane

fruiting-body extract · mycelium powder

A culinary mushroom with genuinely interesting nerve-growth-factor chemistry in the dish, and one tiny elderly-cohort trial in people. The gap between those two facts is where the marketing lives.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

cognition in older adults with mild impairment — grade C, small effect (human-rct)

Mori et al. (2009)

species humandesign RCT, double-blindn 30duration 16 weeksdose 3 g powder/dayfunding not-declaredoutcome cognitive function scale (revised HDS-R)

Scores improved during treatment and declined after stopping — in 30 people, once, with no independent replication in 15 years.

nerve regeneration — grade D, unclear effect (in-vitro)

Grade timeline

No grade movement since first review.

Dosing & safety

TYPICAL SUPPLEMENT DOSE500–3000 mg extract/day

DOSES USED IN STUDIES3 g powder/day in the main human trial

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

OPEN CALCULATOR →