Hyaluronic acid

oral, mixed molecular weights

Famous as an injectable and a skincare ingredient; the oral supplement question is whether swallowing it does anything. Trials exist, are positive, and are almost entirely run by the companies selling it.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

skin hydration & wrinkle depth — grade C, small effect (human-rct)

Oe et al. (2017)

species humandesign RCT, double-blindn 60duration 12 weeksdose 120 mg/dayfunding industryoutcome skin wrinkle measurements, questionnaires

Modest improvement vs placebo, funded and run by a hyaluronan manufacturer — a pattern this claim repeats across nearly every trial.

knee joint pain — grade C, small effect (human-rct)

Grade timeline

No grade movement since first review.

Dosing & safety

TYPICAL SUPPLEMENT DOSE120–240 mg/day

DOSES USED IN STUDIES120–240 mg/day

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

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