CoQ10

ubiquinone · ubiquinol

A mitochondrial electron carrier that declines with age and with statin use. One solid trial in heart failure; a long argument about statin muscle pain.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

outcomes in chronic heart failure (adjunct) — grade B, moderate effect (human-rct)

Mortensen et al. (Q-SYMBIO) (2014)

species humandesign RCT, double-blindn 420duration 2 yearsdose 300 mg/dayfunding industryregistry NCT00374465outcome major adverse cardiovascular events, mortality

Halved cardiovascular mortality as an add-on to standard therapy — a striking result from a modest trial that has not been independently replicated at scale.

statin-associated muscle pain — grade C, unclear effect (human-rct)

Grade timeline

No grade movement since first review.

Dosing & safety

TYPICAL SUPPLEMENT DOSE100–300 mg/day

DOSES USED IN STUDIES100–300 mg/day

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

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