Ca-AKG

calcium alpha-ketoglutarate

A Krebs-cycle intermediate whose levels decline with age, sold as a longevity supplement on the strength of a striking mouse study. The human evidence so far is one small, industry-run trial measuring a methylation clock.

last reviewed 2026-08-30

by draft — unverified

GRADE

CLAIM

SPECIES

EFFECT

STUDIES

slower biological aging (methylation clocks) — grade C, unclear effect (human-rct)

Demidenko et al. (2021)

species humandesign retrospective, single-armn 42duration ~7 months averagedose 1 g/day (Rejuvant)funding industryoutcome TruAge DNA-methylation age

Reported ~8 years of methylation-age reduction — with no control group, run by the product's seller, on a proprietary clock. This is the study that moved the grade from D to C, and every flag on it matters.

healthspan & lifespan extension — grade D, moderate effect (rodent)

Asadi Shahmirzadi et al. (2020)

species rodentdesign controlled lifespan studyn 182duration from 18 months of age to deathdose 2% of chow (Ca-AKG)funding mixedoutcome median lifespan, frailty index in mice

~12% longer median lifespan in females and large frailty reductions in both sexes, started late in life. Impressive — and entirely murine. Nobody has tested this endpoint in humans.

Grade timeline

2026-03

slower biological aging: D → C

First human data appeared (Demidenko 2021 reassessed against our rubric): human, but uncontrolled, industry-run, and biomarker-only — enough for C, nowhere near B.

Dosing & safety

TYPICAL SUPPLEMENT DOSE1–2 g/day

DOSES USED IN STUDIES1 g/day in the human trial; ~510 mg/kg/day in mice

UPPER LIMITnone established

COST SNAPSHOT

No product records for this compound yet.

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