{
  "source": "Evidence Stack",
  "generated": "2026-08-30T07:53:53.032Z",
  "note": "Grades are per claim, never per compound. Full records at /api/compounds/<id>.json",
  "compounds": [
    {
      "id": "creatine",
      "name": "Creatine",
      "synonyms": [
        "creatine monohydrate",
        "creatine HCl"
      ],
      "categories": [
        "muscle",
        "cognition"
      ],
      "bestSupportedClaim": {
        "outcome": "muscle mass & strength with resistance training",
        "grade": "A",
        "effect": "moderate",
        "species": "human-rct"
      },
      "claimCount": 4,
      "studyCount": 7,
      "lastRegrade": "2026-05",
      "url": "https://evidencestack.sebastienwouters.dev/compounds/creatine/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/creatine.json"
    },
    {
      "id": "omega-3",
      "name": "Omega-3 (EPA/DHA)",
      "synonyms": [
        "fish oil",
        "EPA",
        "DHA",
        "icosapent ethyl"
      ],
      "categories": [
        "cardiovascular",
        "cognition",
        "metabolic"
      ],
      "bestSupportedClaim": {
        "outcome": "triglyceride lowering",
        "grade": "A",
        "effect": "large",
        "species": "human-rct"
      },
      "claimCount": 4,
      "studyCount": 6,
      "lastRegrade": "2025-12",
      "url": "https://evidencestack.sebastienwouters.dev/compounds/omega-3/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/omega-3.json"
    },
    {
      "id": "vitamin-d",
      "name": "Vitamin D",
      "synonyms": [
        "cholecalciferol",
        "D3",
        "calcifediol"
      ],
      "categories": [
        "other",
        "cardiovascular"
      ],
      "bestSupportedClaim": {
        "outcome": "correcting measured deficiency",
        "grade": "A",
        "effect": "large",
        "species": "human-rct"
      },
      "claimCount": 3,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/vitamin-d/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/vitamin-d.json"
    },
    {
      "id": "magnesium",
      "name": "Magnesium",
      "synonyms": [
        "magnesium oxide",
        "magnesium citrate",
        "magnesium glycinate",
        "magnesium bisglycinate",
        "magnesium threonate"
      ],
      "categories": [
        "sleep",
        "cardiovascular",
        "metabolic"
      ],
      "bestSupportedClaim": {
        "outcome": "blood pressure reduction",
        "grade": "B",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 4,
      "studyCount": 5,
      "lastRegrade": "2026-01",
      "url": "https://evidencestack.sebastienwouters.dev/compounds/magnesium/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/magnesium.json"
    },
    {
      "id": "nr-nmn",
      "name": "NR / NMN",
      "synonyms": [
        "nicotinamide riboside",
        "nicotinamide mononucleotide",
        "NAD+ precursors"
      ],
      "categories": [
        "longevity",
        "metabolic"
      ],
      "bestSupportedClaim": {
        "outcome": "raising blood NAD+ levels",
        "grade": "B",
        "effect": "large",
        "species": "human-rct"
      },
      "claimCount": 3,
      "studyCount": 3,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/nr-nmn/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/nr-nmn.json"
    },
    {
      "id": "berberine",
      "name": "Berberine",
      "synonyms": [
        "berberine HCl"
      ],
      "categories": [
        "metabolic",
        "cardiovascular"
      ],
      "bestSupportedClaim": {
        "outcome": "glycemic control in type 2 diabetes",
        "grade": "B",
        "effect": "moderate",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/berberine/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/berberine.json"
    },
    {
      "id": "collagen",
      "name": "Collagen peptides",
      "synonyms": [
        "hydrolyzed collagen",
        "collagen hydrolysate"
      ],
      "categories": [
        "other",
        "joint"
      ],
      "bestSupportedClaim": {
        "outcome": "skin elasticity & hydration",
        "grade": "B",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/collagen/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/collagen.json"
    },
    {
      "id": "coq10",
      "name": "CoQ10",
      "synonyms": [
        "coenzyme Q10",
        "ubiquinone",
        "ubiquinol"
      ],
      "categories": [
        "cardiovascular",
        "muscle"
      ],
      "bestSupportedClaim": {
        "outcome": "outcomes in chronic heart failure (adjunct)",
        "grade": "B",
        "effect": "moderate",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/coq10/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/coq10.json"
    },
    {
      "id": "tmg",
      "name": "TMG",
      "synonyms": [
        "trimethylglycine",
        "betaine",
        "betaine anhydrous"
      ],
      "categories": [
        "metabolic",
        "muscle"
      ],
      "bestSupportedClaim": {
        "outcome": "homocysteine lowering",
        "grade": "B",
        "effect": "moderate",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/tmg/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/tmg.json"
    },
    {
      "id": "glucosamine",
      "name": "Glucosamine",
      "synonyms": [
        "glucosamine sulfate",
        "glucosamine hydrochloride"
      ],
      "categories": [
        "joint",
        "longevity"
      ],
      "bestSupportedClaim": {
        "outcome": "knee osteoarthritis pain",
        "grade": "C",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 3,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/glucosamine/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/glucosamine.json"
    },
    {
      "id": "ca-akg",
      "name": "Ca-AKG",
      "synonyms": [
        "calcium alpha-ketoglutarate",
        "alpha-ketoglutarate",
        "AKG"
      ],
      "categories": [
        "longevity"
      ],
      "bestSupportedClaim": {
        "outcome": "slower biological aging (methylation clocks)",
        "grade": "C",
        "effect": "unclear",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 2,
      "lastRegrade": "2026-03",
      "url": "https://evidencestack.sebastienwouters.dev/compounds/ca-akg/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/ca-akg.json"
    },
    {
      "id": "glutathione",
      "name": "Glutathione",
      "synonyms": [
        "GSH",
        "reduced glutathione",
        "liposomal glutathione"
      ],
      "categories": [
        "other",
        "metabolic"
      ],
      "bestSupportedClaim": {
        "outcome": "raising body glutathione stores",
        "grade": "C",
        "effect": "unclear",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/glutathione/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/glutathione.json"
    },
    {
      "id": "glycine",
      "name": "Glycine",
      "synonyms": [
        "aminoacetic acid"
      ],
      "categories": [
        "sleep",
        "metabolic"
      ],
      "bestSupportedClaim": {
        "outcome": "subjective sleep quality",
        "grade": "C",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/glycine/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/glycine.json"
    },
    {
      "id": "hyaluronic-acid",
      "name": "Hyaluronic acid",
      "synonyms": [
        "sodium hyaluronate",
        "HA"
      ],
      "categories": [
        "joint",
        "other"
      ],
      "bestSupportedClaim": {
        "outcome": "skin hydration & wrinkle depth",
        "grade": "C",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/hyaluronic-acid/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/hyaluronic-acid.json"
    },
    {
      "id": "l-theanine",
      "name": "L-theanine",
      "synonyms": [
        "theanine"
      ],
      "categories": [
        "cognition",
        "sleep"
      ],
      "bestSupportedClaim": {
        "outcome": "acute stress & anxiety reduction",
        "grade": "C",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/l-theanine/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/l-theanine.json"
    },
    {
      "id": "lions-mane",
      "name": "Lion's mane",
      "synonyms": [
        "Hericium erinaceus",
        "yamabushitake"
      ],
      "categories": [
        "cognition"
      ],
      "bestSupportedClaim": {
        "outcome": "cognition in older adults with mild impairment",
        "grade": "C",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/lions-mane/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/lions-mane.json"
    },
    {
      "id": "astaxanthin",
      "name": "Astaxanthin",
      "synonyms": [
        "Haematococcus pluvialis extract"
      ],
      "categories": [
        "other"
      ],
      "bestSupportedClaim": {
        "outcome": "skin condition & UV resilience",
        "grade": "C",
        "effect": "small",
        "species": "human-rct"
      },
      "claimCount": 2,
      "studyCount": 0,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/astaxanthin/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/astaxanthin.json"
    },
    {
      "id": "rapamycin",
      "name": "Rapamycin",
      "synonyms": [
        "sirolimus",
        "mTOR inhibitor"
      ],
      "categories": [
        "longevity"
      ],
      "bestSupportedClaim": {
        "outcome": "lifespan extension",
        "grade": "D",
        "effect": "large",
        "species": "rodent"
      },
      "claimCount": 2,
      "studyCount": 2,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/rapamycin/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/rapamycin.json"
    },
    {
      "id": "quercetin",
      "name": "Quercetin",
      "synonyms": [
        "quercetin dihydrate",
        "quercetin phytosome"
      ],
      "categories": [
        "longevity",
        "other"
      ],
      "bestSupportedClaim": {
        "outcome": "clearing senescent cells (senolytic effect)",
        "grade": "D",
        "effect": "unclear",
        "species": "in-vitro"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/quercetin/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/quercetin.json"
    },
    {
      "id": "taurine",
      "name": "Taurine",
      "synonyms": [
        "2-aminoethanesulfonic acid"
      ],
      "categories": [
        "longevity",
        "cardiovascular"
      ],
      "bestSupportedClaim": {
        "outcome": "lifespan & healthspan extension",
        "grade": "D",
        "effect": "moderate",
        "species": "rodent"
      },
      "claimCount": 2,
      "studyCount": 1,
      "lastRegrade": null,
      "url": "https://evidencestack.sebastienwouters.dev/compounds/taurine/",
      "json": "https://evidencestack.sebastienwouters.dev/api/compounds/taurine.json"
    }
  ]
}